Dr. Sang-heon Kim
Cell adhesion to extracellular matrix (ECM) is just as critical in determining cell fate - including cell proliferation, migration, and differentiation - as is the niche environment. Biofunctional materials have accordingly been designed as an artificial ECM (art-ECM) to stimulate cell adhesion and particular cellular functions, resulting in a field appropriately termed “matrix engineering”. In our strategies, we aim to induce the specific differentiation of stem cells via the enhancement of seletcive interactions between such materials and stem cells. The use of bioactive polypeptides, such as growth factor (GF) or cytokine, and employment of fused materials are such examples.